Canon, out of game Jayne Cobb Hoban "Wash" Washburne Inara Serra Malcolm Reynolds River Tam Shepherd Derrial Book Zoe Washburne
In-game friends Allen Gentry Billy Cranston Dean Winchester The Doctor(s) - Five and Ten Fletcher Tringham Jamie McCrimmon Kang Katara Lex Luthor Nanoha Takamachi Wyn Callahan
In-game acquaintances/other Alessa Castiel Charles Kawalsky Dustin Silver Hiccup Jenny Renne Ronon Dex Rose Tyler Sam Winchester Various Engineers
Kaylee
Simon Tam
Canon, out of game
Jayne Cobb
Hoban "Wash" Washburne
Inara Serra
Malcolm Reynolds
River Tam
Shepherd Derrial Book
Zoe Washburne
In-game friends
Allen GentryBilly CranstonDean Winchester
The Doctor(s) - Five and TenFletcher Tringham
Jamie McCrimmonKangKataraLex LuthorNanoha TakamachiWyn CallahanIn-game acquaintances/other
Alessa
Castiel
Charles Kawalsky
Dustin Silver
HiccupJennyRenneRonon Dex
Rose TylerSam Winchester
Various Engineers
...I'm almost positive I'm missing someone.